DCDC2 Back

doublecortin domain containing 2

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NCBI Description of DCDC2

This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Community Annotation of DCDC2 Add / Edit DCDC2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DCDC2 is highly significantly mutated in
DCDC2 is significantly mutated in
DCDC2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DCDC2