DBR1 Back

debranching enzyme homolog 1 (S. cerevisiae)

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NCBI Description of DBR1

The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication.

Community Annotation of DBR1 Add / Edit DBR1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DBR1 is highly significantly mutated in
DBR1 is significantly mutated in
DBR1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DBR1