DBH Back

dopamine beta-hydroxylase (dopamine beta-monooxygenase)

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NCBI Description of DBH
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DBH is highly significantly mutated in
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DBH is significantly mutated in
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DBH is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DBH