DARS2 Back

aspartyl-tRNA synthetase 2, mitochondrial

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NCBI Description of DARS2
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL).

Community Annotation of DARS2 Add / Edit DARS2: Annotations

No community annotations yet for DARS2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DARS2 is highly significantly mutated in
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DARS2 is significantly mutated in
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DARS2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DARS2