DAD1 Back

defender against cell death 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DAD1
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.

Community Annotation of DAD1 Add / Edit DAD1: Annotations

No community annotations yet for DAD1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DAD1 is highly significantly mutated in
(none)
DAD1 is significantly mutated in
(none)
DAD1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DAD1