DACT1 Back

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DACT1

The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of DACT1 Add / Edit DACT1: Annotations

No community annotations yet for DACT1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DACT1 is highly significantly mutated in
(none)
DACT1 is significantly mutated in
(none)
DACT1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DACT1