CYP4B1 Back

cytochrome P450, family 4, subfamily B, polypeptide 1

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NCBI Description of CYP4B1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CYP4B1 is highly significantly mutated in
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CYP4B1 is significantly mutated in
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CYP4B1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CYP4B1