CYP3A4 Back

cytochrome P450, family 3, subfamily A, polypeptide 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CYP3A4

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of CYP3A4 Add / Edit CYP3A4: Annotations

No community annotations yet for CYP3A4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CYP3A4 is highly significantly mutated in
(none)
CYP3A4 is significantly mutated in
(none)
CYP3A4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CYP3A4