CYP39A1 Back

cytochrome P450, family 39, subfamily A, polypeptide 1

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NCBI Description of CYP39A1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CYP39A1 is highly significantly mutated in
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CYP39A1 is significantly mutated in
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CYP39A1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CYP39A1