CYP2C18 Back

cytochrome P450, family 2, subfamily C, polypeptide 18

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NCBI Description of CYP2C18
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CYP2C18 Add / Edit CYP2C18: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CYP2C18 is highly significantly mutated in
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CYP2C18 is significantly mutated in
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CYP2C18 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CYP2C18