CYP2B6 Back

cytochrome P450, family 2, subfamily B, polypeptide 6

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CYP2B6

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Community Annotation of CYP2B6 Add / Edit CYP2B6: Annotations

No community annotations yet for CYP2B6.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CYP2B6 is highly significantly mutated in
(none)
CYP2B6 is significantly mutated in
(none)
CYP2B6 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CYP2B6