CYLD Back

cylindromatosis (turban tumor syndrome)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CYLD
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Community Annotation of CYLD Add / Edit CYLD: Annotations

No community annotations yet for CYLD.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CYLD is highly significantly mutated in
(none)
CYLD is significantly mutated in
(none)
CYLD is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CYLD