CYB5A Back

cytochrome b5 type A (microsomal)

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NCBI Description of CYB5A

The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CYB5A is highly significantly mutated in
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CYB5A is significantly mutated in
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CYB5A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CYB5A