CXCR4 Back

chemokine (C-X-C motif) receptor 4

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NCBI Description of CXCR4
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Community Annotation of CXCR4 Add / Edit CXCR4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CXCR4 is highly significantly mutated in
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CXCR4 is significantly mutated in
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CXCR4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CXCR4