CXCL12 Back

chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

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NCBI Description of CXCL12

This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CXCL12 Add / Edit CXCL12: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CXCL12 is highly significantly mutated in
CXCL12 is significantly mutated in
CXCL12 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CXCL12