CXCL1 Back

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

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NCBI Description of CXCL1
This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CXCL1 is highly significantly mutated in
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CXCL1 is significantly mutated in
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CXCL1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CXCL1