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cubilin (intrinsic factor-cobalamin receptor)

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NCBI Description of CUBN
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CUBN is highly significantly mutated in
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CUBN is significantly mutated in
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CUBN is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CUBN