CTTN Back

cortactin

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CTTN
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Community Annotation of CTTN Add / Edit CTTN: Annotations

No community annotations yet for CTTN.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CTTN is highly significantly mutated in
(none)
CTTN is significantly mutated in
(none)
CTTN is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CTTN