cathepsin O

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NCBI Description of CTSO

The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase.

Community Annotation of CTSO Add / Edit CTSO: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CTSO is highly significantly mutated in
CTSO is significantly mutated in
CTSO is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CTSO