CTSH Back

cathepsin H

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NCBI Description of CTSH
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors.

Community Annotation of CTSH Add / Edit CTSH: Annotations

No community annotations yet for CTSH.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CTSH is highly significantly mutated in
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CTSH is significantly mutated in
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CTSH is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CTSH