CTNND2 Back

catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)

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NCBI Description of CTNND2
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.

Community Annotation of CTNND2 Add / Edit CTNND2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CTNND2 is highly significantly mutated in
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CTNND2 is significantly mutated in
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CTNND2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CTNND2