CTDP1 Back

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CTDP1
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of CTDP1 Add / Edit CTDP1: Annotations

No community annotations yet for CTDP1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CTDP1 is highly significantly mutated in
(none)
CTDP1 is significantly mutated in
(none)
CTDP1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CTDP1