CTBP2 Back

C-terminal binding protein 2

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NCBI Description of CTBP2
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.

Community Annotation of CTBP2 Add / Edit CTBP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CTBP2 is highly significantly mutated in
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CTBP2 is significantly mutated in
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CTBP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CTBP2