CSTF3 Back

cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa

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NCBI Description of CSTF3
The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of CSTF3 Add / Edit CSTF3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CSTF3 is highly significantly mutated in
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CSTF3 is significantly mutated in
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CSTF3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CSTF3