CS Back

citrate synthase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CS

The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found.

Community Annotation of CS Add / Edit CS: Annotations

No community annotations yet for CS.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CS is highly significantly mutated in
CS is significantly mutated in
CS is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CS