CRLF2 Back

cytokine receptor-like factor 2

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NCBI Description of CRLF2
The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CRLF2 Add / Edit CRLF2: Annotations

No community annotations yet for CRLF2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CRLF2 is highly significantly mutated in
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CRLF2 is significantly mutated in
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CRLF2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CRLF2