CRKL Back

v-crk sarcoma virus CT10 oncogene homolog (avian)-like

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CRKL
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

Community Annotation of CRKL Add / Edit CRKL: Annotations

No community annotations yet for CRKL.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CRKL is highly significantly mutated in
(none)
CRKL is significantly mutated in
(none)
CRKL is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CRKL