CRHR1 Back

corticotropin releasing hormone receptor 1

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NCBI Description of CRHR1
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346.

Community Annotation of CRHR1 Add / Edit CRHR1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CRHR1 is highly significantly mutated in
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CRHR1 is significantly mutated in
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CRHR1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CRHR1