CREG1 Back

cellular repressor of E1A-stimulated genes 1

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NCBI Description of CREG1

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CREG1 is highly significantly mutated in
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CREG1 is significantly mutated in
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CREG1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CREG1