CREB3L3 Back

cAMP responsive element binding protein 3-like 3

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NCBI Description of CREB3L3
This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants.

Community Annotation of CREB3L3 Add / Edit CREB3L3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CREB3L3 is highly significantly mutated in
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CREB3L3 is significantly mutated in
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CREB3L3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CREB3L3