CREB1 Back

cAMP responsive element binding protein 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CREB1
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

Community Annotation of CREB1 Add / Edit CREB1: Annotations

No community annotations yet for CREB1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CREB1 is highly significantly mutated in
(none)
CREB1 is significantly mutated in
(none)
CREB1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CREB1