CRADD Back

CASP2 and RIPK1 domain containing adaptor with death domain

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NCBI Description of CRADD
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.

Community Annotation of CRADD Add / Edit CRADD: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CRADD is highly significantly mutated in
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CRADD is significantly mutated in
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CRADD is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CRADD