CPZ Back

carboxypeptidase Z

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NCBI Description of CPZ
This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.

Community Annotation of CPZ Add / Edit CPZ: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CPZ is highly significantly mutated in
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CPZ is significantly mutated in
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CPZ is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CPZ