CPSF3 Back

cleavage and polyadenylation specific factor 3, 73kDa

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NCBI Description of CPSF3

This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing.

Community Annotation of CPSF3 Add / Edit CPSF3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CPSF3 is highly significantly mutated in
CPSF3 is significantly mutated in
CPSF3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CPSF3