coproporphyrinogen oxidase

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NCBI Description of CPOX

The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).

Community Annotation of CPOX Add / Edit CPOX: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CPOX is highly significantly mutated in
CPOX is significantly mutated in
CPOX is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CPOX