CPE Back

carboxypeptidase E

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NCBI Description of CPE
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.

Community Annotation of CPE Add / Edit CPE: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CPE is highly significantly mutated in
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CPE is significantly mutated in
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CPE is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CPE