CPAMD8 Back

C3 and PZP-like, alpha-2-macroglobulin domain containing 8

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NCBI Description of CPAMD8
CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM, Mar 2008].

Community Annotation of CPAMD8 Add / Edit CPAMD8: Annotations

No community annotations yet for CPAMD8.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CPAMD8 is highly significantly mutated in
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CPAMD8 is significantly mutated in
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CPAMD8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CPAMD8