COX6A2 Back

cytochrome c oxidase subunit VIa polypeptide 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of COX6A2
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity.

Community Annotation of COX6A2 Add / Edit COX6A2: Annotations

No community annotations yet for COX6A2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

COX6A2 is highly significantly mutated in
(none)
COX6A2 is significantly mutated in
(none)
COX6A2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for COX6A2