COTL1 Back

coactosin-like 1 (Dictyostelium)

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NCBI Description of COTL1
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

COTL1 is highly significantly mutated in
(none)
COTL1 is significantly mutated in
(none)
COTL1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for COTL1