CORIN Back

corin, serine peptidase

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NCBI Description of CORIN
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.

Community Annotation of CORIN Add / Edit CORIN: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CORIN is highly significantly mutated in
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CORIN is significantly mutated in
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CORIN is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CORIN