corin, serine peptidase

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NCBI Description of CORIN

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.

Community Annotation of CORIN Add / Edit CORIN: Annotations

No community annotations yet for CORIN.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CORIN is highly significantly mutated in
CORIN is significantly mutated in
CORIN is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CORIN