COPS8 Back

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of COPS8
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Community Annotation of COPS8 Add / Edit COPS8: Annotations

No community annotations yet for COPS8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

COPS8 is highly significantly mutated in
(none)
COPS8 is significantly mutated in
(none)
COPS8 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for COPS8