COPS4 Back

COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)

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NCBI Description of COPS4

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of COPS4 Add / Edit COPS4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


COPS4 is highly significantly mutated in
COPS4 is significantly mutated in
COPS4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for COPS4