COL4A2 Back

collagen, type IV, alpha 2

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NCBI Description of COL4A2
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

COL4A2 is highly significantly mutated in
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COL4A2 is significantly mutated in
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COL4A2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for COL4A2