COL25A1 Back

collagen, type XXV, alpha 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of COL25A1

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of COL25A1 Add / Edit COL25A1: Annotations

No community annotations yet for COL25A1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

COL25A1 is highly significantly mutated in
(none)
COL25A1 is significantly mutated in
(none)
COL25A1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for COL25A1