COG8 Back

component of oligomeric golgi complex 8

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of COG8
This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance.

Community Annotation of COG8 Add / Edit COG8: Annotations

No community annotations yet for COG8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

COG8 is highly significantly mutated in
(none)
COG8 is significantly mutated in
(none)
COG8 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for COG8