COG2 Back

component of oligomeric golgi complex 2

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NCBI Description of COG2

This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.

Community Annotation of COG2 Add / Edit COG2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

COG2 is highly significantly mutated in
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COG2 is significantly mutated in
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COG2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for COG2