CNOT7 Back

CCR4-NOT transcription complex, subunit 7

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NCBI Description of CNOT7

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CNOT7 is highly significantly mutated in
CNOT7 is significantly mutated in
CNOT7 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CNOT7