CNOT2 Back

CCR4-NOT transcription complex, subunit 2

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NCBI Description of CNOT2

This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene.

Community Annotation of CNOT2 Add / Edit CNOT2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CNOT2 is highly significantly mutated in
CNOT2 is significantly mutated in
CNOT2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CNOT2