CNNM2 Back

cyclin M2

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NCBI Description of CNNM2

This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of CNNM2 Add / Edit CNNM2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CNNM2 is highly significantly mutated in
CNNM2 is significantly mutated in
CNNM2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CNNM2