CNGB3 Back

cyclic nucleotide gated channel beta 3

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NCBI Description of CNGB3
This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease.

Community Annotation of CNGB3 Add / Edit CNGB3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CNGB3 is highly significantly mutated in
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CNGB3 is significantly mutated in
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CNGB3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CNGB3